Importantly, the antitumor effect of PD-1–laIL-2 was not restricted to the A20 tumor model, and PD-1–laIL-2 had much better control of the tumors than anti–PD-1 plus Erb–laIL-2 in the MC38 colon tumor model (Figure 2B) and even the poorly immunogenic Renca renal tumor model (Supplemental Figure 2A). Here, ESR2 is linked to neoplasm.