S1PR3 and endothelial dysfunction: Inhibition of S1P3 with TY52156 or gene silencing prevented sortilin-induced endothelial dysfunction as well as oxidative stress in mesenteric arteries and HUVECs, whereas these effects were not observed after S1P1 inhibition with W146 or siRNA-mediated knockdown (Figure 2, I and J, Supplemental Figure 5, A and B, and Supplemental Figure 6, A and B).