In a large study of acquired genetic defects (n = 171 Black men), of the top 22 genes mutated in prostate cancers from Black men, only two were found more commonly than in cancers from White men, ZMYM3 (11.7% vs. 2.7%) and FOXA1 (11.7% vs. 5.4%), while mutations at genes like SPOP and TP53 were less often present (98). This evidence concerns the gene SPOP and prostate cancer.