Mutations affecting ZMYM3, encoding a regulator of BRCA1 function, seemed to correlate with widespread unbalanced allele frequencies in the cancers from Black men, suggesting that losses of MAP3K7, RB1, BNIP3L, THADA, and NEIL3 and gains of the genomic region encompassing MYC might underlie aggressive disease behavior (98, 99). Here, ZMYM3 is linked to cancer.