We first analysed the relation between TMPRSS2 rs12329760 and life-threatening SARS-CoV-2 infection in 2,244 critically ill, hospitalized, COVID-19 positive patients from 208 UK intensive care units (ICUs) (Table 1) recruited as part of the GenOMICC (genomicc.org) and ISARIC 4C (isaric4c.net) projects. Here, TMPRSS2 is linked to COVID-19.