GLB1 and chronic obstructive pulmonary disease: Four of our novel signals for ACO were previously reported for asthma but not COPD/lung function.35, 36, 37 For rs35570272 in GLB1 (OR, 1.10; EAF, 0.398; P = 2.44 × 10–9), there were 11 SNPs in the credible set, and the intronic sentinel SNP had the highest posterior probability (0.655).