Another signal (previously reported for asthma)26,35 was rs16903574 (EAF, 0.077; OR, 1.20; P = 3.8 × 10–10), a missense variant in FAM105A, deleterious according to its combined annotation-dependent depletion (CADD) score (22.6).38 The gene discussed is OTULINL; the disease is asthma.