In the multivariable model (Supplemental Figure 6; n = 823 in total; 757 with available outcome data), older age, absence of history of arterial hypertension, chronic renal disease, a shorter delay between symptoms onset and hospital admission, the use of IMV or ECMO as well as creatinine and CRP values on admission were independent significant predictors of in-hospital mortality. This evidence concerns the gene CRP and Hypertension.