LEP and type 2 diabetes mellitus: On the other hand, 4 of 10 SNPs in the positive effect cluster are associated with metabolic traits—rs12328675 and rs2459732 are associated with circulating leptin [70], rs6905288 is associated with type 2 diabetes and thyroid stimulating hormone [71,72], and rs4686696 is intronic to insulin-like growth factor IGF2BP2.