THADA and polycystic ovary syndrome: Of the 4 SNPs in the negative effect cluster, rs2277339 (missense variant in PRIM1 and upstream of HSD17B6, involved in steroid biosynthesis) is associated with primary ovarian insufficiency, early menopause, and PCOS [68,69], and rs11694173 is intronic to THADA, which is also associated with PCOS [47].