CACNA1C and congenital bilateral aplasia of vas deferens from CFTR mutation: Because transgenic expression of CaV1.2, mimicking the increased expression of CaV1.2 associated with CAVD in patients (19), led to the appearance of valve lesions and activation of the dystrophic and osteogenic signaling pathways, we next tested whether administrating a Ca2+ channel blocker (verapamil, 10 mg/kg/d) in vivo via a mini-osmotic pump reduced the appearance of the dystrophic lesions in the Scx-CaV1.2TS model.