Therefore, we cataloged other RAAS signaling components (Supplemental Table 2), many of which are altered in CAVD, such as the Ace2, (Pro)renin receptor (Atp6ap2), and the angiotensin II receptor (Agtr1a), in addition to Agt. This evidence concerns the gene ATP6AP2 and congenital bilateral aplasia of vas deferens from CFTR mutation.