CACNA1C and rheumatoid arthritis: In addition to being components of the gene set for the role of osteoblasts, osteoclasts, and chondrocytes in rheumatoid arthritis, the Nfatc gene products are Ca2+-responsive transcriptional regulators and thus serve as components of sensors capable of translating Ca2+ influx through CaV1.2 to downstream Ca2+-signaling gene expression pathways (37).