KCNQ2 and epilepsy: To demonstrate that automated patch clamp recording is a valid approach for evaluating the functional consequences of epilepsy-associated KCNQ2 variants, we compared data we obtained for 18 variants to results from prior voltage-clamp recording in either mammalian cells or Xenopus oocytes (13, 16, 21, 23–25, 28, 36–41).