Mice lacking homophilic Flrt2 binding specifically in endothelial cells (Cdh5-CreERT2+Flrt2flox/R186N+D188T; referred to hereafter as Flrt2iΔEC/ΔFF mice) showed suppression of tumor growth, angiogenesis, and hemorrhaging, similar to those in Flrt2iΔEC mice (Figure 8, C–E and N–Q). Here, CDH5 is linked to neoplasm.