The secretory proteome of AAT-KO ferrets was characterized by increased APOA1, APCS, A2M, ENO1, and fibrinogen (FGB and FGG), as well as decreased TF and VIM, a profile that is concordant with proteomic investigations comparing patients with COPD and healthy humans (41–43). This evidence concerns the gene ENO1 and chronic obstructive pulmonary disease.