The secretory proteome of AAT-KO ferrets was characterized by increased APOA1, APCS, A2M, ENO1, and fibrinogen (FGB and FGG), as well as decreased TF and VIM, a profile that is concordant with proteomic investigations comparing patients with COPD and healthy humans (41–43). The gene discussed is A2M; the disease is chronic obstructive pulmonary disease.