TGFB1 and systemic sclerosis: PLG treatment induced marked alteration in the transcriptome profile of SSc fibroblasts, as shown by the volcano plot and the heatmap in Figure 8, A and B. TGF-β family genes were substantially downregulated in PLG-treated SSc fibroblasts, whereas healthy control fibroblasts showed more modest transcriptome alterations in response to PLG (Figure 8, A and B).