In this study, we showed that the immune-refractory states of tumor cells over the course of immunoediting process were closely linked to the immune-refractory feature of the TME accompanied by a simultaneous blockade of multiple steps of the antitumor immunity cycle via hyperactivation of the NANOG/HDAC1 axis (Figure 8, A and B). The gene discussed is NANOG; the disease is neoplasm.