Interestingly, the patient with the most severe cognitive impairment in our sample also demonstrated the most elevated Tau PET signal, the highest CSF phospho-Tau and Tau levels, and lowest CSF Aβ 1-42 and Aβ 1-42/ Aβ 1-40 levels, consistent with a typical AD biochemical profile. This evidence concerns the gene MAPT and Alzheimer disease.