SYNGAP1 is a RASopathy that does not have the typical craniofacial features, cardiac issues or skin abnormalities, but has many of the overlapping neurocognitive, behavioral and autistic features found in RASopathies due to the unique neuronal restricted expression of SYNGAP1 (Hamdan et al., 2009). This evidence concerns the gene SYNGAP1 and RASopathy.