In B16-F10 tumor-bearing mice, treatment with PVAX led to potent restoration of a proinflammatory CD8 phenotype in lean and obese mice on day 15 after two doses of therapy, including increased CD8 T cell infiltration, IFN-γ production, and pS6 expression in CD8 T cells from obese mice compared with obese mice treated with a vehicle (Fig. 6 D). The gene discussed is IFNG; the disease is neoplasm.