Similarly, the possibility to stimulate both extrinsic and intrinsic apoptotic pathways to overcome cancer multidrug resistance (MDR) using a magnetic switch and controlled receptor aggregation has been described.113 In this case, 15 nm Zn0.4Fe2.6O4 MNPs were modified with doxorubicin (Dox, an anticancer drug) using a cleavable disulphide linker and targeted to the death receptor 4 (DR4) by monoclonal antibodies. The gene discussed is TNFRSF10A; the disease is cancer.