Through systematic analysis, the top 10 of each GO term include “immune system process,” “inflammatory response,” “innate immune response,” “cellular response to IFN-γ,” “apoptotic process,” “cytosol,” and “protein binding”; and the top 15 of KEGG pathways include “antigen processing and presentation,” “TNF signaling pathway” and “type 1 diabetes”. The gene discussed is TNF; the disease is type 1 diabetes mellitus.