An EBUS scan revealed non-necrotizing granuloma in a COPD patient, who was reviewed for sarcoidosis treatment. A nodule biopsy was also performed on the patient to rule out cancer sarcoid syndrome. A poorly differentiated adenocarcinoma of the lung was reported that was positive for GATA3, P63, CK7, and TTF-1. The patient underwent surgical intervention, and no signs or symptoms of systemic sarcoidosis were documented. According to the study, identifying cancer earlier improves the patient's outcome and prognosis. The gene discussed is TP63; the disease is chronic obstructive pulmonary disease.