Lane et al. and Swanson et al. discussed the pathology of steroids-induced osteoporosis as it works as an anti-anabolic and decrease the effects of growth hormone (GH), insulin growth factor-1 (IGF-1), and insulin growth factor binding protein 3-4-5 (IGFBP3-4-5), which leads to an increase in RANKL and a decrease in OPG. The gene discussed is TNFRSF11B; the disease is osteoporosis.