Androgen is a natural hormone in the body that converts into estrogen and plays a vital role in decreasing bone resorption; corticosteroid use, in addition to the inflammatory process of CD, decreases dehydroepiandrosterone sulfate (DHEA), leading to a defect in androgen levels, reducing estrogen; thus, it affects bone remodeling, causing low BMD and osteoporosis as the normal process of estrogen increases OPG, which is a bone resorption marker [9]. The gene discussed is TNFRSF11B; the disease is osteoporosis.