Based on the similarity between Atg7 deficiency and vitiligo phenotypes, especially concerning the activation of Nrf2 regulated genes, oxidative stress, and premature senescence, it is very likely that autophagy-deficient melanocytes and vitiligo melanocytes share defective cellular redox regulation, increased membrane lipid oxidation, and premature senescence. The gene discussed is NFE2L2; the disease is vitiligo.