The level of ROS increases in the skin lesions of vitiligo, while the expression of antioxidant enzymes such as catalase (CAT), glutathione reductase (GPX), thioredoxin (Trx)/thioredoxin reductase (TrxR), and methionine sulfoxide reductase (Msr) A and B is downregulated [20, 21]. This evidence concerns the gene CAT and vitiligo.