Ren et al. showed that activation of Sirt1-FOXO1 and PI3K-Akt signaling pathways can control blood glucose metabolism, reduce ROS production, inhibit OS and myocardial cell apoptosis, delay cardiac complications, and achieve the purpose of alleviation or even treatment of diabetic cardiomyopathy [74]. Here, SIRT1 is linked to diabetic cardiomyopathy.