The heat map revealed that SH3KBP1|88643|AP and ZFYVE20|63554|ES might have positive effects on HNSCC, while AGTRAP|670|AA, SH3KBP1|88642|AP, RHOT1|40176|ES, PTGR1|87219|AA, MOBP|64191|AT, ABCC5|67820|RI, C5orf30|72920|AP, FKTN|87134|ES, and RBPMS|83290|AT exhibited a contrary effect (Figure 4(c)). The gene discussed is MACIR; the disease is head and neck squamous cell carcinoma.