However, recent studies have indicated that PPARδ is involved in various diseases such as a variety of cancers (Müller, 2017 ▸), non-alcoholic fatty liver disease (NAFLD; Zarei et al., 2021 ▸) and neuroinflammation (Strosznajder et al., 2021 ▸). This evidence concerns the gene PPARD and metabolic dysfunction-associated steatotic liver disease.