CCL2 and snowflake vitreoretinal degeneration: We showed that vascular Nox2 increases in severe SVD, confirming the importance of oxidative damage as a critical mechanism in human SVD,71 and our hypothesis on the role of Nox2 in human ageing-related brain pathology.39 Furthermore, we confirmed an associated increase of indices of microvascular inflammation, especially immune mediator and chemoattractant factor CCL2 (MCP1).