Some of these genes have been well characterized in lung cancer, for instance, NAPSA29 is a common prognostic marker for LUAD, and KRT18, KRT7, and GPRC5A have been reported to play important roles in tumor progression and chemoresistance in various types of cancers.30, 31, 32, 33, 34, 35, 36, 37. This evidence concerns the gene KRT18 and cancer.