CpG site cg10045354 was significantly associated with an increased risk of CRC (OR = 1.67, 95% CI: 1.47‐1.89, P = 3.54 × 10−16), and located on the CpG island mapping to gene COLCA2 and COLCA1, which are key molecules involved in immunity and defense and have been identified as CRC susceptibility genes (Figure S4). This evidence concerns the gene COLCA1 and colorectal carcinoma.