POU2AF3 and colorectal carcinoma: CpG site cg10045354 was significantly associated with an increased risk of CRC (OR = 1.67, 95% CI: 1.47‐1.89, P = 3.54 × 10−16), and located on the CpG island mapping to gene COLCA2 and COLCA1, which are key molecules involved in immunity and defense and have been identified as CRC susceptibility genes (Figure S4).