To confirm our data, we measured the intracellular lipid accumulation and triglyceride synthesis using radiolabelled tracers in human hepatoma cells (Huh7 cells) homozygous for the PSD3 186L allele, and obtained virtually identical results as McA-RH7777 cells (Supplementary Fig. 6). This evidence concerns the gene PSD3 and hepatocellular carcinoma.