We prioritized KCNJ15 for functional validation because (1) this locus showed the greatest enrichment for upregulated monocyte DA peaks, (2) the DA peaks coincided with an SE, (3) its role in monocyte physiology, infection and inflammation has not been previously studied and (4) potassium channels have not been studied in the context of mycobacterial infection. The gene discussed is KCNA3; the disease is infection.