KCNMA1 and sudden infant death syndrome: In a 3-months-old SIDS case, we found a new sequence alteration (S1173G) of uncertain significance in KCNMA1. The role of calcium-activated potassium channels (maxi-K+ channel; gene KCNMA1) in oxygen-sensing in the CB is still not fully understood but these channels seem to be required for the spiking behavior of chemo-sensitive cells in the CB under acute hypoxia, development of the CB and adaption to high altitude.48 This new variant might have interfered with CB development and/or acute hypoxia-sensing and thereby could have co-contributed to the death of the infant.