LIN28A and neoplasm: Subsequently, we further analyzed the effect of YAP1 on LIN28A-regulated tumorigenesis and cell migration/invasion phenotypes in vitro and in vivo, and found rescue of YAP1 expression in LIN28A knockdown CAL51 cells could potentially improve the tumor growth of xenografts, and the cell migration/invasion abilities caused by LIN28A downregulation (Figs. 4F–M and S4M, N).