HSPA5 and acute myeloid leukemia: To target cell surface GRP78-positive AML cells, we designed GRP78-CARs with one (1x), two (2x), or three (3x) copies of the GRP78-specific peptide23, which we used for flow cytometry analysis, as an antigen recognition domain (GRP78.1x-, GRP78.2x-, GRP78.3x-CAR).