HSPA5 and acute myeloid leukemia: To evaluate if GRP78.1x-CAR T cells can sequentially kill AML cells and produce cytokines we performed a repeat stimulation assay in which NT, GRP78.ΔCAR, or GRP78.1x-CAR T cells (Effector cells) were stimulated every 3 days with MOLM13.GFP.ffluc cells (Target cells) (Fig. 4a).