Subsequently, we constructed a predictive model for the prognosis of osteosarcoma through univariate COX regression analysis, Lasso regression analysis, and multivariate COX regression analysis and screened five genes related to the prognosis of osteosarcoma, which included ST3GAL4, TRIM8, STC2, TRPS1, and FAM207A. The gene discussed is ST3GAL4; the disease is osteosarcoma.