To double-check the action of estrogen-regulated Fpr2 expression in NAFLD, ovariectomized WT female mice were supplemented estradiol (OVX-E2) or placebo pellets (OVX-P), then were fed chow or CDAHFD for 12 weeks (Supplementary Fig. 15a). Here, FPR2 is linked to metabolic dysfunction-associated steatotic liver disease.