In fact, when compared across the three groups (SR, GHR, and FHR), these signatures are not significantly different between SR and FHR (HMCL7, UAMS80, UAMS70, EMC92, IFM15, and CINGEC) or between GHR and FHR (PI, HZDCD, CINSARC, CI, CIN70, and PR), although the indices associated with chromosomal instability (CINSARC, CI, and CIN70) or tumor aggression (PI and PR) appear to be generally higher in the FHR patients (Fig. 2B). Here, GHR is linked to neoplasm.