Most important, we observed a significantly higher predictive accuracy (larger AUCs) of the AhR/Wnt-markers enriched AIC-scores compared to BICLC–score in the subgroup of SCLC patients (p  = 0.019; AUCAIC  = 0.577 AUCBIC  = 0.546) within the test set (see Additional file 1: Figure S4). This evidence concerns the gene AHR and small cell lung carcinoma.