STAT3 and myocardial infarction: IL-6 family/STAT3 signaling has been reported to be involved in myocardial regeneration mediated by the dedifferentiation and proliferation of cardiomyocytes, observed in the myocardium of neonatal rodents, as well as amphibians and fish [38], and lack of IL-6 production caused functional deterioration after myocardial infarction [39, 40].