In this study, although eosinophil count and total IgE were increased in the SE IgE-sensitization group, neither SA carriage nor SE IgE-sensitization was causally related to asthma, allergic rhinitis, dyspnea within the last 12 months and wheezing within the last 12 months (Additional file 1: Table S3). The gene discussed is IGHE; the disease is asthma.