Firstly, analysis of the basal glycolysis/OXPHOS ratio revealed that both SKOV3 and H808910 cells preferred glycolysis in our experimental conditions, and the result is shown in Supplementary Fig. 3A. To test whether TRPM7 silencing could shift the glucose metabolic reprogramming, we measured the levels of glucose consumption and lactic acid production in the sh-control and TRPM7 silencing ovarian cancer cells. Here, TRPM7 is linked to ovarian cancer.