Similar patterns of the relative levels of HK2, PDK1, IDH3B and UQCRC1 proteins were detected in these cells by Western blot and immunofluorescence (Fig. 3D and E), and the statistical analysis is shown in Supplementary Fig. 4A. PKM2 is a key enzyme for glycolysis and its nuclear translocation is associated with malignant behaviors of tumor cells [23]. This evidence concerns the gene PKM and neoplasm.