EGFR and Familial prostate cancer: This CTC isolation kit targeted EPCAM, EGFR, ERBB2: EPCAM expression is present on the surface of epithelial cells and it plays an important role in prostate cancer proliferation, invasion, metastasis [23]; EGFR expression is observed in CTC during prostate cancer metastasis and it promotes survival of prostate tumor-initiating cells and CTC that metastasize to bone; ERBB2 expression is elevated in bone metastases of prostate cancer.