Although ado-trastuzumab emtansine (T-DM1) and fam-trastuzumab deruxtecan-nxki (T-DXd) are recommended as treatment options for advanced HER2-mutant NSCLC patients by the National Comprehensive Cancer Network (NCCN) guidelines based on ORRs of 44% (N = 18) and 72.7% (N = 11), respectively in advanced HER2-mutant lung adenocarcinomas, these two drugs have not been approved yet for treating this subset of patients [4, 5]. The gene discussed is ERBB2; the disease is lung adenocarcinoma.