Part of data of this trial (ChiCTR1800020262) was published recently which has shown the efficacy of pyrotinib in NSCLC patients with HER2 amplification (6-month PFS rate: 51.9%, ORR: 22.2%, mPFS: 6.3 months, mOS: 12.5 months) [33]. Here, ERBB2 is linked to non-small cell lung carcinoma.