In a phase II study (N = 60) conducted by Zhou C et al., chemotherapy-treated NSCLC patients with HER2 mutations within exon 20 and 19 achieved an ORR of 30% upon pyrotinib, with mPFS of 6.9 months and median overall survival (mOS) of 14.4 months [11]. Here, ERBB2 is linked to non-small cell lung carcinoma.