ERBB2 and non-small cell lung carcinoma: Chemotherapy remains the current standard-of-care for HER2-mutated NSCLC; however, it typically yields an ORR of 10–43.5% (1st-line, 43.5%; 2nd-line, 10%) and a PFS of 4.3-6 months (1st-line, 6 months; 2nd-line, 4.3 months) [6, 7].