The results of the study showed that the ethyl acetate extract of S. emarginatum could up-regulate the expression of Bax mRNA (2500 μg/ml, 3000 μg/ml group) and Caspase-3mRNA (2000 μg/ml, 2500 μg/ml, 3000 μg/ml group) in HepG2 cells of liver cancer, and down-regulate the expression of Bcl-2 mRNA (3000 μg/ml group) in HepG2 cells. This evidence concerns the gene BCL2 and liver cancer.