Altogether, most of the previously published data highlight the increase of cancer cells’ sensitivity to the anticancer treatments in the presence of different classes of antibiotics; yet, this study shows that among the seven tested antibiotics, CFT and CFP (two cephalosporins that belong to the ß-lactams class of antibiotics) antagonized significantly 5-FU-induced cell death in HCT-116 and DLD-1 cells (Figs. 2 and 3). Here, CFP is linked to cancer.