A preoperative CEA level ≥ 5 ng/mL, a high number of NLN (≥27 in the right-side colon and ≥ 12 in the left-side colon), and TNM stage IIIC disease were three independent prognostic factors for RFS and OS in right-side and left-side stage III colon cancer. This evidence concerns the gene CEACAM5 and colonic neoplasm.