Fortunately, we found that intended knockdown of C12orf48 by shRNA markedly up-regulated the expression of PCBP1, which was involved in the process of pre-mRNA, mRNA stabilization and translation and was validated responsible for cancer growth and metastasis functioning as a novel tumor-suppressive factor9 (Fig. 3A-C). The gene discussed is PARPBP; the disease is neoplasm.