Table 1 showed a significantly irrelevant relationship between C12orf48 over-expression and age, gender, histological subtypes, vessel cancer embolus, pTNM stage, tumor size (all P > 0.05), while C12orf48 overexpression was significantly in relate to T3-4 depth of invasion (53.7% v.s. 21.4%, P < 0.05), positive perineural invasion (73.7% v.s. 44.4%, P < 0.05) and positive nodal metastasis (56.4% v.s. 32.9%, P < 0.05) between the two groups. The gene discussed is PARPBP; the disease is neoplasm.