We found that simultaneous overexpressing KDM6B and SNAI1 had reduced the weight of mice (Additional file 2: Fig. S2E), whereas food intake showed no significant difference (Additional file 2: Fig. S2B), and the subcutaneous fat weight was reduced (Additional file 2: Fig. S2C), alleviated liver steatosis by reducing lipid droplet accumulation (Fig. 5C; Additional file 3: Fig. S3G). Here, SNAI1 is linked to fatty liver disease.