A previous study had reported that ISL1 could cooperate with KDM6B to mediate downstream genes, KDM6B could remove the methylation of SNAI1, and the low expression of SNAI1 promoted fat synthesis of NAFLD (Liu et al. 2018; Sui et al. 2019; Wang et al. 2016). This evidence concerns the gene SNAI1 and metabolic dysfunction-associated steatotic liver disease.