After overexpression of ISL1/KDM6B/SNAI1 in NAFLD mice, c-caspase 3 and c-caspase 7 levels were decreased, but c-caspase 3 and c-caspase 7 levels were increased when overexpressing ISL1 simultaneously inhibiting SNAI1, or overexpressing KDM6B simultaneously inhibiting SNAI1 (Additional file 7: Fig. S7C). Here, ISL1 is linked to metabolic dysfunction-associated steatotic liver disease.