A previous study had reported that ISL1 could cooperate with KDM6B to mediate downstream genes, KDM6B could remove the methylation of SNAI1, and the low expression of SNAI1 promoted fat synthesis of NAFLD (Liu et al. 2018; Sui et al. 2019; Wang et al. 2016). Here, ISL1 is linked to metabolic dysfunction-associated steatotic liver disease.