IFN-γ is secreted in the colon by infiltrating immune cells, and in agreement, analysis of colonic tissue during C. rodentium infection showed a general increase in myeloid and lymphocytic cell lineages from 8 to 20 DPI (Fig. 4K and Fig. 5A; Fig. S4B), with the exception of conventional dendritic cell (cDC) numbers (CD11b+ DCs), which showed minimal changes over the infection course (Fig. S4B). The gene discussed is IFNG; the disease is infection.