The enhanced IFN-β release by GSDMD seems a common scenario in RNA virus infection since it was observed in poly(I·C) stimulation and PDCoV infection, in contrast to the study of GSDMD in modifying microbial DNA-induced IFN-I production during bacterial infection showing that GSDMD dampens cGAS-dependent IFN-I elicitation by promoting intracellular K+ efflux (45). Here, GSDMD is linked to bacterial infectious disease.