The higher circulating levels of the endogenous anticoagulant proteins s-thrombomodulin and TFPI in the presence of hyperferritinemia likely reflect increased shedding from the activated vascular endothelium, which is expected to result in a loss of their cell-associated anticoagulant properties and to stimulate a procoagulant phenotype [31, 33]. Here, THBD is linked to isolated hyperferritinemia.