However, while levels of gB, gK, and ICP0 transcripts were significantly lower in Avil-SPP-/- neurons than control mice on both days 2 and 5 post ocular infection, they did not significantly differ in total RNA isolated from TG on day 2 (Fig 4B, Fisher’s exact test) and day 5 (Fig 4D, Fisher’s exact test). This evidence concerns the gene GK and eye infection.